All functions |
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A container for geneset definitions. |
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Fetches the GeneSetDb from MultiGSEAResult |
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A MultiGSEAResult object holds the results from a multiGSEA call. |
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Add metadata at the geneset level. |
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Checks equality (feature parity) between GeneSetDb objects |
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Annotates rows of a data.frame with geneset membership from a GeneSetDb |
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Appends two GeneSetDb objects togethter. |
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Utility function to run limma differential expression analysis |
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Gene Set Collection Metadata |
Combines two GeneSetDb objects together |
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Combines two MultiGSEAResult objects together. |
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(Re)-map geneset IDs to the rows in an expression object. |
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Convert a GeneSetDb to other formats. |
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Plots the correlation among the columns of a numeric matrix. |
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Runs GSEA on a pre-ranked list of differential expression statistcis with fgsea |
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Performs goseq analysis significance of gene set membership. |
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Single sample gene set score by a weighted average of the genes in geneset |
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Functions that load data for use in examples and testing. |
Utility function to try and fail with grace. |
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Fetch the featureIdMap for a |
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Returns the relevant featureIds for a given geneset. |
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Fetches information for a gene set |
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Summarize geneset:feature relationships for specified set of features |
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Fetch the active (or all) gene sets from a GeneSetDb or MultiGSEAResult |
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Summarizes useful statistics per gene set from a MultiGSEAResult |
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Retrieves a housekeeping GeneSetDb for a given species |
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Retrieves a GeneSetDb from KEGG's REST API |
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Fetches a |
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Get pathways/GOslim information from PANTHER.db Biocondcutor package. |
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Retrieve annotations from reactome.db |
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Perform goseq Enrichment tests across a GeneSetDb. |
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Single sample geneset score using SVD based eigengene value per sample. |
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Converts collection,name combination to key for geneset |
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Check to see if the GeneSetDb has a collection,name GeneSet defined |
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Check if a collection exists in the |
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Creates a 1/0 matrix to indicate geneset membership to target object. |
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Visualize gene level behavior of genes within a geneset across a contrast. |
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Interrogate "active" status of a given geneset. |
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Load the mouse or human ensembl <-> entrez id maps. |
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Extract the individual fold changes statistics for elements in the expression object. |
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Creates a "geneset smart" ComplexHeatmap::Heatmap |
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Creates a "geneset smart" ComplexHeatmap::Heatmap |
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Utility function to cat a message to stderr (by default) |
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Performs a plethora of GSEA analyses over a contrast of interest. |
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Lists the supported GSEA methods by multiGSEA |
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Performs an overrepresentation analysis, (optinally) accounting for bias. |
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Assembles a matrix of nominal or adjusted pvalues from a multiGSEA result |
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Just like eigenWeightedMean but direct from PCA (no gsdscore) |
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Plots bias of coviarate to DE / selected status |
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Converts the feature identifiers in a GeneSetDb to a set of new ones. |
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Smartly/easily rename the rows of an object. |
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Interrogate the results of a multiGSEA analysis stored in a MultiGSEAResult |
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Centers and scales the rows of a numeric matrix. |
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Generates single sample gene set scores across a datasets by many methods |
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Match a species query to the regularized species info. |
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Normalize a vector of ssGSEA scores in the ssGSEA way. |
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Subset whole genesets from a GeneSetDb |
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Subset GeneSetDb to only include specified genesets. |
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Subset a GeneSetDb to only include geneSets with specified features. |
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Summarizes different results into tabular form |
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Validate the input objects to a GSEA call. |
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Create an interactive volcano plot |
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Extracts x and y axis values from objects to create input for volcano plot |
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Calculate single sample geneset score by average z-score method |
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Z-tranfsorm a vector of pvalues |