ssGSEA normalization (as implemented in GSVA (ssgsea.norm)) normalizes the individual scores based on ALL scores calculated across samples AND genesets. It does NOTE normalize the scores within each geneset independantly of the others.

ssGSEA.normalize(x, bounds = range(x))

Arguments

x

a numeric vector of ssGSEA scores for a single signature

bounds

the maximum and minimum scores obvserved used to normalize against.

Value

normalized numeric vector of x

Details

This method is an internal utilit function and not exported on purpose